Aromatase in the Human Brain

The conundrum some men face is that estrogen levels tend to increase as testosterone levels do. As part of the steroidogenesis pathway, testosterone is metabolized into either dihydrotestosterone (DHT) by the 5-alpha reductase enzyme or estradiol by the aromatase enzyme. These case reports illustrate the important contribution of estrogens to male health and identify the possible indications and risks of aromatase-inhibitor treatment in men. They may be used to increase gonadotropin secretion and thereby stimulate Leydig and Sertoli cell function. Aromatase inhibitors may be used to prevent or delay epiphysial closure and thereby increase adult height.

Osteoporosis Risk

Using aromatase inhibitors can also affect men’s metabolism and cardiovascular health. These changes can be significant and may require lifestyle adjustments or medical interventions to manage effectively. Decreasing Estrogen, such as by consuming natural aromatase inhibitors, can improve many different diseases and symptoms, such as Asthma, Dementia & Alzheimer’s, Depression & Anhedonia, and Hypothyroidism. A deficiency in magnesium increases aromatase, and most people are deficient in this nutrient.

Natural Estrogen Blockers for Men: Which Aromatase Inhibitors Are Best?

The following section will break down the research highlighting naturally occurring compounds that act as estrogen blockers. Research suggests the common table mushroom has anti-aromatase22 properties and therefore possible anti-estrogen activity. Chinese women who consumed mushrooms and green tea had a 90% lower incidence of breast cancer.23 However the study was relatively small (2,018 patients participating) and limited to Chinese women of southeast China.

A 2018 study in the Journal of Clinical Oncology also noted that the risk of diabetes was 240% greater in women on aromatase inhibitors than in the general population. Although the risk was far lower with tamoxifen, aromatase inhibitors do not pose the risk of thromboembolism (blood clots) or endometrial cancer that tamoxifen does. Women on aromatase inhibitors are at a two- and four-fold increased risk of bone loss compared to a matched set of women in the general population, says a 2015 review in the Journal of Bone Oncology. The long-term effects of aromatase inhibitors are arguably more concerning. Unlike tamoxifen, aromatase inhibitors tend to speed up osteopenia (bone loss) in older women who are already at risk https://animprops.com/growth-hormone-before-and-after-understanding-the-2/ of bone problems. Aromatase inhibitors are not effective in premenopausal women unless they are combined with ovarian suppression because they mainly inhibit the estrogen produced in the fat tissue and not in the ovaries.

Given the importance of E2 in male physiology and the impact of TTH on E2, careful monitoring by practitioners providing exogenous therapy is critical. This retrospective study in Indian males showed insignificant effect of AI in gynecomastia and IHH, significant effect in CDP and some benefit in improving seminal parameters. Moreover, this study highlights the importance of estimating E2 (along with T and gonadotropins) in various endocrinopathies, which can be benefitted by reducing E2 by AI. Therefore, inhibiting beta-glucuronidase (via calcium D-glucarate) may help lower levels of estradiol and estrogen metabolites by increasing their rate of elimination 17. So the less aromatase you have, the more testosterone is allowed to remain in its free form.

• Anabolic Health aspires to become a trusted resource where men can come and learn how to fix their hormonal problems naturally, without pharmaceuticals.
• Testosterone and estrogen are very closely related and testosterone is converted into estradiol, a form of estrogen.
• There was marked improvement in SMR in case A with “sole” therapy with letrozole, but insignificant response in gynecomastia.
• As a result, your testosterone will escalate from being healthier, as well as from the decrease in body fat.

In addition, a man’s body increases aromatase activity when men have sudden increases in androgen levels. This includes taking testosterone therapy or supplements that increase this hormone. The increase in aromatase is the cause of many of the unwanted side effects of androgen therapy, including gynecomastia, moodiness, impotence, infertility, and a decrease in testicular size. In the Breast International Group’s Femara-Tamoxifen trial, also known as BIG 1–98, 5 years of adjuvant letrozole was compared with 5 years of tamoxifen in postmenopausal women with ER-positive and/or PgR-positive breast cancer. Eventually, this trial was modified with the addition of two treatment groups in which women were either switched from tamoxifen to letrozole or from letrozole to tamoxifen after the initial 2 years of treatment (26).

A case study describes a morbidly obese infertile man, who after a similar treatment with anastrozole showed a normalized pituitary-testis axis, spermatogenesis and fertility 46. However, testosterone levels will also improve on weight loss 47, which is the intervention of choice for obese men with or without low testosterone levels. In three small studies, letrozole or testolactone has been administered to morbidly obese men to improve their testosterone levels 42-44. In addition, aromatase inhibitors for men supplements can decrease the effects of excessive estrogen in men already taking supplements to increase androgen levels. These effects include gynecomastia (increase in fatty breast tissue) and moodiness. Increased estrogen can destroy the masculine appearance and outlook that many men are seeking.